NaturaLift MD Review Blog

Archive for the ‘wrinkle reduction that works’ Category

NexDerma® Naturalift MD: Advanced Face Lift Therapy helps block, mitigate, and reverse the effects of ultraviolet radiation on the skin through the ingredients described below.

BHT

“The fact that only a modest, measured protective effect can elicit a dramatic decrease in actinic damage (particularly with regard to cancer) upholds this concept as an important goal.”

This resulted from scientific research conducted by the Photobiology Laboratory on the oral effects of BHT. However, when BHT is ingested with food, it’s very diluted by the time it reaches the skin. Topical applications of BHT were studied in depth. “… BHT offered significant protection (against ultraviolet light mediated sunburn) when applied topically.” Topically applied BHT blocks the cancer causing agent (TPA) from stimulating the cancer-causing enzyme ODC by 80 percent.

“These results demonstrate an early and direct inhibition of TPA-induced ODC activity by lipophilic phenolic antioxidants (including BHT) and suggest a role for reactive oxygen and/or free radical species in tumor promotion.”

CoenzymeQ-10 (Ubiquinone)

It’s essential to avoid the sun. And, never forget to apply a skin protective therapy containing the correct concentration of coenzyme Q-10 and the natural forms of vitamin E (alpha, beta, gamma, and delta tocopherols, and tocotrienols).

Doctors and skin research scientists report that:

“Coenzyme Q-10, or Ubiquinone, is a nutrient - a vitamin-like substance which plays a crucial role in the generation of cellular energy and in free radical scavenging in the human body. After the age of 35 to 40, the organism (YOU) begins to lose its ability to synthesize CoQ-10 from food, and its deficiency develops. Aging, poor eating habits, stress and infection - they will all affect your ability to provide adequate amounts of CoQ-10.”

Extra-Virgin Olive Oil

Extra virgin olive oil is a potent antioxidant. When applied before exposure to UV-B, experiments have demonstrated it helps protect the skin from developing cancer. This result was also documented when extra virgin olive oil was applied to the skin after UV-B exposure. Dermatologists conducting the study reported:

“Mice that received extra virgin olive oil after UV-B exposure showed significantly lower numbers of tumors per mouse than those in the UV-B control group throughout the experimental period.”

Another study reported that:

“…there were lower levels of 8-hydroxy-2-deoxyguanosine (8-OHdG: a carcinogenic agent) in epidermal nuclei. These results indicate that extra virgin olive oil topically applied after UV-B exposure can effectively reduce UV-B-induced murine skin tumors (by 62%), possibly via its antioxidant effects in reducing DNA damage by reactive oxygen species.”

“In this study the effects of hydroxytyrosol (DOPET), the major antioxidant compound present in extra virgin olive oil on UV-A induced cell damages, have been investigated using human melanoma cells.”

Further: “… [t]hese protective effects are dose dependent.”

Doctors studied the effect of extra virgin olive oil topically-applied to the skin before each of multiple doses of x-rays: “… [t]he data indicated a definite radioprotective effect of the topical administration of extra virgin olive oil.”

Authors of a related article pointed out that: “… regular olive oil neither retarded nor reduced skin cancer formation in UV-irradiated mice. Our results suggest that daily topical use of extra virgin olive oil after sunbathing may delay and reduce UV-induced skin cancer development in human skin, possibly by decreasing reactive oxygen species-induced 8-OHdG which is responsible for gene mutation.”130 They also noted that: “…[a]ntioxidants vitamin E and epigallocatechin-3-gallate (EGCG) extracted from green tea, applied topically to the skin, delayed the onset of UV-induced skin cancer in mice.”

Ginkgo Biloba Extract

Applied to the skin, this compound is very protective against the free radical
generation caused by UV-B irradiation. Ginkgo biloba extract is both protective against ultraviolet radiation and therapeutic, even when applied after exposure. When tested orally, ginkgo biloba extract protected skin from ultraviolet radiation better than orally-ingested beta carotene and vitamin E. Ginkgo biloba extract controls stress-induced free radicals.

Ginseng Extract (Panax)

Ginseng extract:

“…significantly reduced ultraviolet-B induced cell death and protected human keratinocytes from apoptosis caused by ultraviolet-B irradiation.” Biochemically it “…prevented ultraviolet-B-induced cleavage of poly (ADP-ribose) polymerase (a critical enzyme) in keratinocytes. In search of the molecular mechanism responsible for the anti-apoptotic effect of the ginseng extract, we find that protection from ultraviolet-B-induced apoptosis is tightly correlated with the ginseng extract mediated inhibition of ultraviolet-B-induced down-regulation (decreasing the genetic molecular activity) of Bcl-2 (toxic compound) and Brn-3a (toxic compound) expression.”

Green Tea Extract & EGCG

Since many of the toxic reactions causing aging in cells were accelerated by a combination of UV-A and/or UV-B plus topically applied toxic chemicals, experiments were performed to see how effectively EGCG prevents photoaging. The results were very impressive: from excellent to good, depending on doses of sunlight, toxic chemical and type used, and the amount of EGCG applied. Many documented both anti-cancer and anti-photoaging effects of EGCG.

EGCG protects the extracellular matrix (ECM) from oxidative stress from ultraviolet radiation.

“EGCG can reverse the ECM degradation induced by UV even with a topical application of a practical-use concentration. In particular, EGCG proved to be much more effective in ROS-related conditions, such as UVA exposure.”

Magnesium-L-Ascorbyl-Phosphate (Vitamin C)

Magnesium-L-ascorbyl-phosphate, a form of vitamin C (ascorbic acid), is absorbed into the skin where it is continuously and safely converted into ascorbic acid. It is not acidic like l-ascorbic acid, which stings and burns skin and is a serious danger to the eyes.

“Pretreatment with magnesium-L-ascorbyl-phosphate significantly prevented such photo-damage as sunburn cell formation, DNA fragmentation and lipid (fatty compounds such as cell membranes) peroxidation which were caused by a single dose of UVB irradiation. These results [of this study] suggest that the protective effect of magnesium-L-ascorbyl-phosphate on UVB-induced cutaneous damage is due to the maintenance of a normal ascorbic acid level by conversion of magnesium-L-ascorbyl-phosphate to ascorbic acid in skin tissue.”

Can topically-applied ascorbic acid protect skin against UV-B radiation? No:

“In this study, AsA (also known as ascorbic acid) could not inhibit cytotoxicity, but AA-2P (Ascorbyl phosphate) and AA-2G was able to cancel the harmful effect of UV-B when treated at high levels of 0.5-5 mM.”

Magnesium-L-ascorbyl-2-phosphate is a potent antioxidant, protecting the skin from ultraviolet sunlight.

“…after acute and chronic exposure to UVB irradiation … administration of magnesium-L-ascorbyl-2-phosphate immediately after acute exposure to 15kJ/m¹ of UVB significantly prevented increases of UVB-induced lipid peroxidation in skin. Administration of magnesium-L-ascorbyl-2-phosphate immediately after each exposure significantly delayed skin tumor formation and hyperplasia induced by chronic exposure to UVB. Magnesium-L-ascorbyl-2-phosphate, once converted in the skin to ascorbic acid, exhibits such inhibitory effects by scavenging hydroxyl and lipid radicals generated as a direct or indirect result of UVB exposure.”

Note: Ascorbyl palmitate (C-ester) is toxic to skin cells when applied topically and exposed to sunlight, as noted by the prestigious Mayo Clinic.

Resveratrol

Resveratrol is an antioxidant more powerful than vitamin E. It was compared to seven other well known antioxidants that are used to preserve food, including vitamin E. Resveratrol was very potent in stopping lipid peroxidation. It was also good at scavenging the hydroxyl-activated ion (OH), beating out vitamin E in both essential categories of antioxidant function. But neither was effective against hydrogen peroxide (H2O2). That’s why the correct combinations of potent antioxidants are required for optimal protection.

Resveratrol applied topically to the skin is photo-chemo-protective against acute and chronic sunlight damage, decreases tumor-causing enzymes, and protects lipids and related critical substances.

Doctors at the University of Wisconsin Department of Dermatology studied the chemopreventive effects of resveratrol against UV-B radiation-mediated skin tumorigenesis. They concluded: “… [t]he topical application of skin with Resveratrol resulted in a highly significant 1) inhibition in tumor incidence, and 2) delay in the onset of tumorigenesis. Interestingly, the post-treatment of Resveratrol was found to impart equal protection
than the pretreatment; suggesting that Resveratrol-mediated responses may not be sunscreen effects.”

Superoxide Dismutase

Doctors at the Jefferson Medical College Department of Dermatology and Cutaneous Biology showed the power of superoxide dismutase “… to protect against ultraviolet-A and ultraviolet-B induced damage. The ability of superoxide dismutase to prevent radiation-induced elastin promoter activation was determined in vivo. Superoxide dismutase (analog Temprol) provided over 50% protection against ultraviolet B and over 70% protection against ultraviolet A.” They recommended this agent “… to prevent cutaneous aging.”

A study of comparing biopsies of sun-damaged skin of young volunteers with biopsies of undamaged control sites:

“In photo-aged skin, a significant depletion of antioxidant enzyme superoxide dismutase expression was observed within the stratum corneum and in the epidermis. Importantly, an accumulation of oxidatively modified proteins was found specifically within the upper dermis.”

Skin cells were subjected to sunlight, and volunteers were also subjected to 10 days of sunlight.

“Exposures of keratinocytes and fibroblasts to ultraviolet B, ultraviolet A, and hydrogen peroxide led to a dose-dependent protein oxidation and thus confirmed in vivo results. In conclusion, the correlation between photo-damage and protein oxidation was demonstrated for the first time, which hence may be a relevant pathophysiologic factor in photo-aging.”

This directly relates to how oxidative stress hastens cellular death: “… [w]hen the cells are grown under conditions of oxidative stress, cellular longevity is markedly shortened.” This occurs despite the Hayflick Limit, where the “… human maximal lifespan can be equal to about 145 years.”

Titanium Dioxide

Only titanium dioxide (Ti02) offers protection against all varieties of ultraviolet radiation. Fortunately, it also provides 80% to 100% protection against blue light.

It was considered that the inorganic metal oxides such as titanium dioxide and zinc oxide only reflected sunlight. But, “… [t]his is not the case with modern micronized forms of metal oxides. It has been shown that both zinc oxide and titanium dioxide mobilize electrons within their atomic structure while absorbing UV radiation.” They reflect and neutralize UV by absorbing the energy, as sun blocks should. These researchers, and many others, concluded that titanium dioxide, as well as zinc oxide, “…are stable, non-toxic, and safe, and they act as highly efficient UV attenuators.”

In a series of exquisite experiments, researchers used very fine particulate titanium dioxide at concentrations of 1%, 5%, and 10% against three increasingly higher doses of UV-B radiation. They also compared these results to the well known sunscreens of para-aminobenzoic acid (PABA) and urocanic acid, each at a 1% concentration. The control was plain petrolatum. They determined the effect of UV-B on the DNA of living skin. The results showed that both PABA and the urocanic acid provided poor protection, while titanium dioxide gave 100% protection at the 1% solution level. DNA was unchanged from the non-irradiated controls. The protection achieved by a 5% concentration was the same as with 1%, but was effective against double the level of UV-B radiation.

Vitamin A

A major study evaluating the effectiveness of retinaldehyde (a safe and effective topical precursor of vitamin A) found that:

“…UV-A exposure induced significant alterations of collagen and elastic fibers. In all UV-A exposed and then retinaldehyde-treated skin specimens, collagen and elastic fibers were restored to the level of non-exposed skin.”

Vitamin D3 (Cholecalciferol)

In an extensive study, scientists applied the active form of vitamin D3 (cholecalciferol) to the exposed skin of albino hairless mice before each UV exposure. Then the mice were exposed to ultraviolet radiation at a moderate strength (11 J/cm¹) for two hours a day, five days per week, for 20 weeks. Wrinkles formed in the untreated skin. This was documented in photographs. Microscopically, there was a loss of fat cells and an increase of fibrous tissue. No wrinkles were seen in skin topically treated with cholecalciferol; microscopically, the skin remained normal.

“…[V]itamin D3 is efficacious against fibrosis (scar tissue formation) in the lower dermis induced by chronic solar-stimulating UV irradiation. The application of vitamin D3 on the dorsal skin prior to irradiation prevented the disappearance of adipocytes. Taken together, solar-stimulating UV irradiation effects on the proliferation and differentiation of skin cells including adipocytes, fibroblasts, and keratinocytes, resulted in hyperplasia (thickening) of epidermis and fibrosis (scar tissue formation) of adipose tissue. Cholecalciferol prevents these phenomena.”

Vitamin E (Natural Alpha Tocopherol and Tocotrienols)

The natural forms of vitamin E (alpha tocopherol and tocotrienols) are fat-soluble antioxidants that scavenge many free radicals, including lipid peroxyl radicals. Vitamin E absorbs only UV-B, not UV-A (vitamin A absorbs both UV-B and UV-A). However, the stratum corneum is very depleted of alpha-tocopherol following a single acute exposure to either UV-A or UV-B, or both. The destruction of the surface-level alpha tocopherol is also caused by the secondary effects of ultraviolet irradiation that generates free radicals.

Vitamin E has been demonstrated to decrease the severity of UV-caused skin wrinkling by 75% and also significantly decreases erythema and edema from UV injury.

Zinc Oxide

Zinc helps prevent UV-B cell apoptosis, even when it is used after exposure. Zinc can also protect fibroblast cells, allowing them to resist the oxidative stress from both UV-A and UV-B.

A zinc solution was tested to see if it protects skin from ultraviolet light so intense that it would be two times the minimal dose needed to cause sunburn. It was applied topically either five days in a row or one time two hours before exposure. Both methods reduced the percentage of sunburn cells.

In other experiments, researchers also tested the topical use of zinc to see what, if any, effect it would have when applied topically one or two hours after ultraviolet light exposure. In this, zinc even offered 25% protection when applied as late as one hour after ultraviolet exposure, but none when initially applied two hours after exposure. The zinc oxide in NexDerma® Naturalift MD: Advanced Face Lift Therapy provides continuing protection.

Dimethicone

When tested against a chemical known to cause irritant contact dermatitis (sodium lauryl sulfate), dermatologists at the University of California School of Medicine stated:

“This study demonstrated that appropriate dimethicone skin protection products may provide certain benefits from surfactant irritant contact dermatitis. The skin protection lotion may be used to prevent irritant contact dermatitis in home or work environments, where skin irritants may induce dermatitis or eczema.”

Dexpanthenol (Vitamin B5)

Many medical professionals suffer from irritant-caused dermatitis or from a contact dermatitis (such as a reaction to poison ivy). 38% of 262 subjects had severe skin stress, 31% had severely dry skin, and 17% had dermatological diseases of the hands. After just three weeks of topical application of dexpanthenol:

• 79% rated their skin condition as improved or normal.
• 95% rated their results as good or very good compared with the awful condition of their skin before beginning treatment, and against problems experienced with other forms of treatment.

Contact allergy from dexpanthenol is very rare, and the FDA recognizes dexpanthenol as Generally Recognized As Safe. Dexpanthenol has been referred to as atoxic; in fact, it has been used to treat dry eyes and to aid healing corneal ulcers that often result from the overuse of contact lenses.

Ginkgo Biloba Extract

Ginkgo biloba extract has been shown to be very non-allergenic, even in highly allergic patients. Furthermore, it has demonstrated strong anti-allergy activity in patients whose skin is highly reactive to contact dermatitis. In tests, ginkgo biloba proved to be an anti-irritant substance for the skin. Among many substances tested for their anti-irritant protection of skin, ginkgo biloba was among the few noted to be beneficial.

Ginkgo biloba extract stimulates fibroblast cells to secrete healing collagen. In addition to enhancing the amount of collagen in aging skin, it is also anti-inflammatory. Other positive benefits of ginkgo biloba include the fact that it:

• Stops the loss of skin pigmentation and aids re-pigmentation in cases of vitiligo.
• Stimulates skin circulation.
• Increases blood flow to the brain in patients with demonstrated arteriosclerotic lesions.
• Demonstrates positive benefits in patients suffering from polyneuropathies.

Zinc Oxide

The body requires zinc in a salt form, which is a form of zinc (zinc +2) attached to an ion. Zinc salts, unlike other metal salts of nickel and chromium, do not cause contact allergy as noted in the very sensitive local lymph node assay test for contact allergens.

Dynamic Wrinkle Injections like Botox, Dysport, and Myobloc are the three FDA-approved drugs. All three paralyze the facial muscles: they are derived from the poison excreted by the bacteria clostridium botulinum. Paralyzed facial muscles atrophy and can eventually cause loss of texture and increased sagging.

In adults, botulism is caused by the oral ingestion of the preformed toxin found in contaminated food. In infants, this paralyzing disease is usually caused by the ingestion of live bacteria, most often from non-pasteurized honey. In both adults and children, botulism causes progressive paralysis and results in death from paralysis of the respiratory muscles, unless the victim receives ventilator support in an Intensive Care Unit.

The correct topical nutrients in their optimal concentrations can prevent and heal the many diverse conditions which damage and age your skin. NexDerma® Naturalift MD: Advanced Face Lift Therapy helps mitigate and reverse the effects of skin problems using the ingredients described below.

How The Naturalift MD: Advanced Face Lift Therapy Dramatically Reduces Wrinkles  In Your Skin

Coenzyme Q-10 (Ubiquinone).  Fifteen German doctors and scientists stated in a recently published study about coenzyme Q-10:

“We have investigated whether topical application CoQ-10 has the beneficial effect of preventing photoaging. We are able to demonstrate that CoQ-10 penetrated into the viable layers of the epidermis and reduced the level of oxidation measured by weak photon emission. Furthermore, a reduction in wrinkle depth following CoQ-10 application was also shown. CoQ-10 was determined to be effective against UV-A mediated oxidative stress in human keratinocytes(Cells in the primary outer layer of our epidermis.) in terms of thiol depletion, activation of specific phosphotyrosine kinases(A class of enzymes.) and prevention of oxidative DNA damage. CoQ-10 was also able to significantly suppress the expression of collagenase(The harmful enzyme that dissolves the skin’s collagen.) in human dermal fibroblasts following UV-A irradiation. These results indicate that CoQ-10 has the efficacy to prevent many of the detrimental effects of photoaging.”

Here’s how ten skin specialists described the results of their skin studies using coenzyme Q-10:

“We demonstrated a diminished resistance in keratinocytes of old donors against UV irradiation. This reduced epidermal resistance against oxidative stressors, i.e.: UV irradiation, can be improved by topical application of CoQ-10.”  They also stated “Our in vivo investigations shows that wrinkles around the region of the eyes could be reduced by long-term application of CoQ-10.”

Dosage is critical for best results. Doctors performed experiments to evaluate the penetration of coenzyme Q-10 in the skin. They stated: “… [c]oenzyme Q-10 skin levels were found to be directly related to the concentration employed and the contact time.” In another study which evaluated topical application and skin levels CoQ-10, researchers observed: “… high concentrations of CoQ-10 may be achieved in the skin by topical treatment.”

In another experiment, researchers used only a 0.05% concentration of topical coenzyme Q-10, and achieved: “… a significant increase that peaked after 60 days.” However, this increase was only in the sebum(The fatty substance secreted on top of the skin). There was no significant concentration in the stratum corneum(The outermost epidermis layer).

Therefore, concentration is very important. That’s why we based ours on science: to give you the most effective concentration available. As the pervious authors stated: “Coenzyme Q-10 levels were found to be directly related to the concentrations employed and the contact time…” That’s why we use a high concentration and recommend application at least twice a day to maximize the affect of our optimally formulated Therapy.

DMAE.  A 2005 randomized clinical study published in the prestigious American Journal of Dermatology found that topical use of DMAE:

“…applied daily for 16 weeks has been shown to be safe and efficacious in the mitigation of forehead lines and periorbital(Periorbital=around the eyes) fine wrinkles, and in improving lip shape and fullness and the overall appearance of aging skin. These effects did not regress during a 2-week cessation of application. Beneficial trends were noted in the appearance of course wrinkles, under-eye dark circles, nasolabial folds, sagging neck skin, and neck firmness. Application was noted to be well tolerated, with no difference in the incidence of erythema, peeling, dryness, itching, burning or stinging between DMAE and placebo groups. Long-term application of DMAE for up to one year was associated with a good safety profile. The acute skin-firming effects of DMAE have been confirmed by quantitative measures of cutaneous tensile strength. DMAE is a moderately active anti-inflammatory agent.”

Ginseng Extract (Panax).  Topically-applied ginseng extract markedly reduced inflammation. As reported in 2005, ginseng is a herb that contains compounds “… that possesses anti-tumor effects, including inhibition of invasion, metastasis, and angiogenesis, and induction tumor cell apoptosis. Tumor promotion often accompanies an elevated ornithine decarboxylase (ODC) activity, acute inflammation and induction ofcyclooxygenase-2 (COX-2) activity.”

Glucosamine Sulfate.  The most vivid example of age reversal in the skin is achieved using topical glucosamine sulfate: obvious wrinkles are erased day by day. Most people begin to see a real change within one week of using NexDerma® Naturalift MD: Advanced Face Lift Therapy twice daily. For more information, see Appendix B.  Glucosamine sulfate is required to manufacture hyaluronic acid; production markedly diminishes in adults. As a result, we lose the look and texture of the skin of our youth, but this is reversible.

Grape Seed Extract. Grape seed extract protects the microscopic blood vessels inside the skin, and thereby helps to prevent wrinkles:

“Besides erythema and sunburn reactions, UVB stress can promote erythrocyte extravasation from skin capillaries and hemolysis, and photo-sensitized hemoglobin can in turn lead to an overload of free radicals in dermis (skin) which exacerbates photo-damage. Grape seed procyanidins dose-dependently delay the onset of hemolysis. EGCG was less potent. Since grape seed procyanidins inhibit the formation of phospholipid hydroperoxides of the inner and outer layers of the red blood cell membrane, their strong anti-lipo-peroxidant activity, may maintain in vivo the integrity of red blood cells in sub-epidermal capillaries and effectively counteract in dermis the onset/exacerbation of the UVB-induced skin photo-damage.”

Green Tea Extract & EGCG.  EGCG significantly reduces and inhibits inflammation of the skin.

Green tea reverses the aging process in epidermal cells and reduces tumor growth, too. The topical use of green tea extract with EGCG significantly increases the metabolic level of keratinocytes. Here’s what doctors from medical colleges in the US and Japan said in 2003:

“The most abundant green tea polyphenol EpigalloCatechin-3-Gallate (EGCG), was found to induce differential effects between tumor cells and normal cells.”

EGCG stimulates only non-cancerous cells. The report also stated: “… [a]ged keratinocytes, which exhibited low basal cellular activities after culturing in growth medium for up to 25 days, renewed DNA synthesis and activated succinate dehydrogenase up to 37-fold upon exposure to either EGCG or the polyphenols.”

Niacinamide (Vitamin B3).  Aging skin produces less of the fatty substance, ceramide, that helps the keratinocytes serve as the normal barrier that prevents water loss. Niacinamide stimulates ceramide synthesis, helping reduce the appearance of aging.

“Niacinamide is a more effective moisturizer than white petrolatum on atopic dry skin, and may be used as a treatment in atopic dermatitis.”

A clinical study of topically applied niacinamide in July of 2005 found:  “Analyses of the data revealed a variety of significant skin appearance improvement effects for topical Niacinamide: reductions in fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness. In addition, elasticity was improved. …In addition to previously observed benefits for topical Niacinamide, additional effects were identified.”

In 2005, dermatologists at the University of Cincinnati performed a clinical human study that clearly demonstrated the power of niacinamide to erase facial hyperpigmented skin lesions.

Resveratrol. “… decreases the proliferation of skin fibroblast cells, to decrease scar tissue and prominent wrinkles.”

Superoxide Dismutase. Dermatologists at the University of Cologne stated:

“Reactive oxygen species generated in the skin by UV irradiation promote photoaging and photocarcinogenesis. Superoxide dismutase is a primary antioxidant enzyme that crucially contributes to the homeostasis of oxygen radicals within the mitochondria, and thus critically participates in the control of senescence and tumor generation.”

When topically applied to the skin, it has a special ability to reverse the vasoconstriction to the skin, and this reversal of vascular spasm occurs “… when reactive oxygen species are scavenged by superoxide dismutase.”

Superoxide dismutase works strongly against photoaging, a factor of increasing importance because:

“The recent increase of ultraviolet rays on the Earth due to the increasing size of the ozone hole is harmful to life and to accelerate premature photo-aging of the skin. The detrimental effects of UV radiation on the skin are associated with the generation of reactive oxygen species such as superoxide anion radical, hydrogen peroxide, hydroxyl radical, and singlet oxygen. In this study, we report first in vivo detection and imaging of the generated reactive oxygen species in the skin of live mice following UVA irradiation. In addition, we found that the superoxide radical is formed spontaneously and singlet oxygen is generated in the UVA-irradiated skin.”

Note:     The superoxide oxygen radical is the specific target for the superoxide dismutase antioxidant enzyme. That’s one of the main reasons we included it in our Naturalift MD: Advanced Face Lift Therapy formula.

To evaluate sugar-caused advanced glycenation end-products (AGE) and its ability to cause more harm from sunlight exposure, researchers conducted a detailed biochemical study on human skin fibroblast cells. They reported:

“To clarify a possible role of advanced glycation end-products (AGE) on photoaging of human skin, the interaction between AGE and ultraviolet-A light was examined from both a biological and chemical perspective. Human dermal fibroblasts that were exposed to UVA and AGE exhibited significant decrease of cell viability. Unstable free radicals including hydrogen peroxide and hydroxyl radicals, were also generated. The reaction was inhibited by addition of superoxide dismutase in the system.”

Ursolic Acid.  Topically applied, ursolic acid reduces wrinkles in the skin by increasing the natural collagen content in skin. This benefit is achieved by increasing the production of fibroblast cells in the dermis as well as increasing the ceramide content of the epidermis. Ursolic acid “… prevents premature aging of the skin.”

“Ursolic acid significantly suppressed UVA-induced reactive oxygen species production and lipid peroxidation. Pretreatment with ursolic acid significantly reduced the UVA-induced activation and expression of MMP-2. In addition, UVA-induced enhanced expression of p53, a hallmark of UV-induced DNA damage and cell death, was also significantly inhibited by pretreatment with ursolic acid. Taken together, these results suggest that ursolic acid may be an effective inhibitor of UVA-modulated signal transduction pathways in human skin cells. These results further suggest that this agent may be useful in the prevention of UVA-induced photo-aging.

Vitamin A (Retinyl Palmitate & Retinol). A one-year study on facial skin aging and topically applied retinaldehyde reported:  “…[c]ompared to the control group, retinaldehyde treatment induced a significant increase in epidermal thickness of the temple, as well as cutaneous (skin) elasticity. Retinaldehyde has counteracting effects on skin aging.”  Retinyl palmitate and Retinol are two of the safe precursors of vitamin A.

The biological reasons for many of the anti-photoaging effects of retinol include:

“…vitamin A, retinol, and retinaldehyde have free radical scavenging potential. Due to their physical properties, they absorb UV light in the region of the solar spectrum that is responsible for the most deleterious biological effects of the sun.”

and

“…Interfering with this UV-induced vitamin A deficiency (using topical vitamin A precursors) is a new concept for the prevention of skin cancer and aging.”

A measurement for the amount of DNA damage is the amount of thymine dimers present in the skin. Skin loaded with vitamin A as retinyl-esters, after applying sufficient amounts of retinol, retinyl palmitate, and retinaldehyde topically, and exposed to sunlight sufficient to cause four times the minimal erythema dose, reduced production of thymine dimers by 43%. In human subjects, this form of topical therapy:

“…was as efficient as a sun protection factor 20 sunscreen in preventing sunburn erythema as well as the formation of thymine dimers. These results demonstrate that epidermal retinyl esters have a biologically relevant filter activity and suggest, besides their pleomorphic biologic actions, a new role for vitamin A that concentrates in the epidermis.”

Naturalift MD: Advanced Face Lift Therapy contains powerful and safe natural nutrients for the skin that can be topically applied daily, forever. NaturalLift MD does not have artificial colors, fragrances or paraben preservatives so it is safe to use twice daily for maximum benefits.  These have been scientifically proven to block the toxic actions of free-radical oxidants and carcinogens, as well as inflammatory, carcinogenic, and aging compounds created within the skin in reaction to their negative effects.

Along with other powerful and natural ingredients below, NaturaLift MD is proven to prevent cancer and but also enhance cell renewal.  These and  28 concentrated antioxidants, vitamins, minerals and herbal extracts that work together as a powerful team to safely and effectively reverse the signs of aging.  It significantly reduces wrinkles and hyper-pigmentation and heals irritated and damaged skin while reducing the risk of skin cancer  and slowing further skin degeneration.

Ellagic Acid (from Pomegranate Seed Extract)

When topically applied, ellagic acid (ofthese antioxidants tested: ellagic acid, alpha-tocopherol (vitamin E), ferulic acid, and curcumin.) “… exerted the strongest effect to suppress lipid peroxide of skin and augmented the viability of skin flaps.”

Ginkgo Biloba Extract

Applied topically to the skin, ginkgo biloba extract has a strong anti-inflammatory activity by “… inhibiting by 65% the production of prostaglandin E2 and markedly suppressing induction of COX-2.” Ginkgo biloba extract, applied to the skin, is a potent free radical scavenger.

Niacinamide (Vitamin B3)

This nutrient has very strong anti-inflammatory properties which cause a significant improvement in acne. By reducing inflammation, niacinamide decreases leukocyte peroxidase enzymes that lead to localized skin damage and thereby improves the appearance of the skin. It helps suppress inflammation caused by white blood cells when triggered by antigens.

Squalane

Squalane helps stop and prevents chronic skin inflammation:

“The physical, chemical and biochemical factors that accelerate skin aging have been proposed to activate a self-maintained micro-inflammatory process, one of the expected end results of which is an imbalance in the turnover of macromolecules in the dermis. Surface peroxides are recognized as controllable factors of skin aging, and their accumulation is attributed to environmentally induced impairment of defense enzymes. Topical application of antioxidants decreases the rate at which skin elasticity and skin thickness is modified.”

Superoxide Dismutase

Superoxide dismutase was studied for its ability to heal scalded skin (scalding skin results in second-degree, and sometimes third-degree, burns) with the least amount of damage. Scientists at the Institute of Applied Microbiology reported:

“Highly reactive metabolites, such as oxygen free radicals, initiate a cascade of inflammatory processes in the thermally damaged skin, leading to enhanced tissue loss and delayed wound healing. The extent of tissue necrosis in the zone of stasis is of prognostic significance in the wound healing process. The findings of this study indicate that superoxide dismutase treatment resulted in reduced and faster recruitment of edema formation, smaller wound sizes, and minor transformation to necrosis compared to the controls, thus resulting in significantly faster reepithelialization after three weeks.”

Ursolic Acid

Ursolic acid is a potent anti-inflammatory agent, as shown by the results quoted from these tests:

“Topical application of ursolic acid inhibited TPA-induced inflammation, ornithine decarboxylase activity, and tumor promotion. … [t]opical application of ursolic acid together with TPA twice weekly for 20 weeks to DMBA-initiated mice inhibited the number of tumors per mouse by 61%.”

Ginkgo biloba extract has been shown to be very non-allergenic, even in highly allergic patients. Furthermore, it has demonstrated strong anti-allergy activity in patients whose skin is highly reactive to contact dermatitis. In tests, ginkgo biloba proved to be an anti-irritant substance for the skin. Among many substances tested for their anti-irritant protection of skin, ginkgo biloba was among the few noted to be beneficial.

Ginkgo biloba extract stimulates fibroblast cells to secrete healing collagen. In addition to enhancing the amount of collagen in aging skin, it is also anti-inflammatory. Other positive benefits of ginkgo biloba include the fact that it:

•    Stops the loss of skin pigmentation and aids re-pigmentation in cases of vitiligo.
•    Stimulates skin circulation.
•    Increases blood flow to the brain in patients with demonstrated arteriosclerotic lesions.
•    Demonstrates positive benefits in patients suffering from polyneuropathies.

Ginkgo biloba extract is an outstanding nutrient for the skin. It:

•    Enhances skin collagen production.
•    Stimulates skin circulation.
•    Protective against sunlight.
•    Strong anti-inflammatory activity.
•    Anti-allergy activity in skin.
•    Helps reduce skin pigment loss, aids repigmentation.
Ginseng Extract (Panax)

Ginseng is an herbal plant grown throughout the Orient where it has been used to protect and improve the internal body and skin health of many millions of people for thousands of years. Topically applied, ginseng extract benefits you by:

•    Stimulating skin hyaluronic acid production and reduces wrinkles.
•    Markedly reducing inflammation.
•    Blocking carcinogens from causing skin cancer.
•    Enhancing skin immune protection.
•    Protecting skin cells from UV-B irradiation.
•    Helping skin fight malignant melanoma cell growth.
•    Stimulating hair follicles.

Science has documented how extracts of ginseng work at the biochemical and cellular level to prevent and fight cancer, inhibit inflammation, enhance the skin’s immune system, and aid hair growth. It also has many positive benefits when taken orally — one claim is that it improves sexual performance.

Researchers specializing in herbal medicine have written this about ginseng:

“Recently, there have been considerable efforts to search for naturally occurring substances that can inhibit, reverse, or retard the multi-stage carcinogenesis. A wide array of phenolic substances derived from edible and medicinal plants have been reported to possess anti-carcinogenic and anti-mutagenic activities and in many cases, the chemo-preventive activities of phytochemicals (molecular compounds from plants) are associated with their anti-inflammatory and/or anti-oxidative properties. Ginseng has been widely used in traditional herbal medicine for the treatment of various diseases.”

Along with other powerful and natural ingredients NaturaLift MD is proven to prevent cancer and but also enhance cell renewal.  These and  28 concentrated antioxidants, vitamins, minerals and herbal extracts that work together as a powerful team to safely and effectively reverse the signs of aging.  It significantly reduces wrinkles and hyper-pigmentation and heals irritated and damaged skin while reducing the risk of skin cancer  and slowing further skin degeneration.

Here’s the secret to why you’re spending all your time and money on products that don’t work: most products you purchase are not at the optimal concentrations.  This occurs for many reasons, but essentially, the correct topical nutrients in their optimal concentrations can prevent and correct the many conditions that can damage and age your skin.

NexDerma® Naturalift MD: Advanced Face Lift Therapy helps ‘reverse’ skin problems by using the ingredients described in this guide. If you want more scientific details on each ingredient, read the articles associated with each nutrient in our Bibliography.

Almost every skin lotion and skin cream is based on the same general formula: water and some form of oil or grease such as mineral oil or petroleum jelly, plus an emulsifier to allow the water and oil to fully mix into a stable emulsion.

What are cosmetic skin-care products? Little more than what is described above with some fragrance, inferior forms of some diluted nutrients, and lots of hype plus visually-attractive packaging, and you have what appears in almost endless varieties in every supermarket, drugstore, and cosmetics counter.

Cosmetics are cover-ups and, if used, should be used knowingly for that purpose. They aren’t therapeutic; they don’t - they cannot - reverse the ill effects on the skin of all the elements, natural and otherwise, that attack it today.

Would you like to look younger today? NexDerma® has developed a scientifically-formulated new product to improve your skin naturally: Naturalift MD: Advanced Face Lift Therapy.

Have you ever wondered why a child’s skin is so soft and smooth? What causes our skin, one of the body’s most vital organs, to show its age? More importantly, what can we do to stop, or even reverse, that aging process?

Our skin loses hyaluronic acid, collagen and elastic fibers over time. The skin that is left is often degraded, rough and dull. Naturalift MD: Advanced Face Lift Therapy revamps the skin by providing the necessary absorbed topical nutrients, a treatment which feeds and rejuvenates the skin. As wrinkles fade, a youthful softness develops, blemishes vanish and sagging is replaced by firmness.

NexDerma® Naturalift MD: Advanced Face Lift Therapy is based on the most up-to-date science and medical information available. We used the research of thousands of independent physicians and scientists from hundreds of prestigious universities and research centers — centers such as Harvard University, The Johns Hopkins University, the Cleveland Clinic, Stanford University, the M.D. Anderson Cancer Center, and the Mayo Clinic — so that you can learn how to safely and effectively reverse the signs of aging. We know that, after you use this product line, you’ll love the beneficial effects it has on your skin.

This guide shows you the science behind the response of skin to the topical application of many nutrients in optimum forms and concentrations.

Dr. Valerie Rosenbaum is a dermatologist who specializes in anti-aging skin care and explains well how NaturaLift MD differs from the big budget ultra rich cosmetic products out on the market:

Heavily advertised skin care anti wrinkle cream contains the worst ingredients. The company spends more money on advertising than research and development. So, what you end up with is a pretty bottle with a designer name and a nice fragrance, but few effective ingredients and cheap fillers.

Anti wrinkle creams and lotions that are really safe and effective are not sold in department stores and the companies don’t advertise on TV. They don’t need to. Their products are so good that they sell by word of mouth, alone.

The most important component is antioxidants. Dermatologists have found that older skin cells produce more free radicals and contain fewer antioxidants

Look for coenzyme Q10, vitamin E, wakame kelp, honey, avocado, macadamia, olive oil, grape seed oil and amino acid protein peptides.

These ingredients provide moisture, prevent protein loss, destroy free radicals, kill bacteria, provide essential fatty acids and protect.

In other words, they do all of the things that skin care anti wrinkle cream should do, without causing any harmful effects. Your health and safety should always come first.

[Source]

In many scientific studies, ellagic acid has proven itself again and again to be a potent topically-applied anti-cancer nutrient. In 2005, doctors at the prestigious University of California Department of Radiation Oncology determined that ellagic acid is one of the most effective compounds they tested of twenty against cancer. “The assay has a predictive accuracy of approximately 91.4%… ” in animal testing and … is responsive at clinically achievable concentrations.”

Ellagic acid has potent anti-inflammatory effects and reduces skin cancer risks. You’ve consumed this very potent anti-oxidant and anti-cancer nutrient numerous times since it is very plentiful in many fruits, including grapes. This very potent anti-inflammatory and anti-cancer nutrient is not toxic to skin cells.

Throughout your youth, from the time you’re a new-born baby, a young child, a teen, and in to adulthood, your skin had a certain healthy tone, a glow and radiance.

But as you grow older your skin changes.

Well what if you could slow down that process? Maybe even reverse it.

Science has come a long way toward unlocking the secrets of what makes up this exact chemistry of your skin, revealing the medical basis behind the reason for the vitality that shows on your face when you look and feel your best.

NaturalLift MD offers the benefits of that research into how to look younger, improve your skin texture, skin tone, reduce wrinkles and fine lines and start looking better.

It’s the most scientifically based and the best natural anti-aging facial treatment available today.

NaturalLift MD combines 28 concentrated antioxidants, vitamins, minerals and herbal extracts that work together as a powerful team to safely and effectively reverse the signs of aging.

It significantly reduces wrinkles and hyper-pigmentation and heals irritated and damaged skin while reducing the risk of skin cancer  and slowing further skin degeneration.

The secret behind NaturalLift MD is the research that went into its formulation.

Our independent medical and scientific consulting team searched for the most effective and highest quality ingredients.

They evaluated other skin care products in their clinics.

The team researched independently published medical and scientific articles on each of the selected nutrients
as well as many other common skin care ingredients to determine which were documented to be safe and effective.

The researchers took their study even further and look at important factors that are often overlooked-the optimum concentration and specific active forms of each nutrient.

NaturalLift MD is based on a result of over 1100 independent published medical and scientific studies from accredited research centers and universities such as Harvard University,  Johns Hopkins University,
the Cleveland Clinic, M.D. Anderson Cancer Clinic, the Mayo clinic and the National Institutes of Health.

We have detailed these information research in our free book: your prescription for ageless skin.

This is a complete educational guide for your skin.

You’ll learn how to safely and naturally reverse the signs of aging, reduce your risks of skin cancer
and optimize your skin’s health, vitality and appearance.

In addition, the book documents the medical and scientific research behind each nutrient in our NaturalLift MD and how each benefits your skin.

We invite you to view your free copy online at http://www.naturaliftmd.com

Our free book allows you to open each reference study for more information from the National Library of Medicine’s website.

The patent-pending combination of 28 nutrients at optimum concentrations in NaturalLift MD is medically and scientifically proven to:

• dramatically decrease the appearance of wrinkles and fine lines

• decrease the appearance of age spots, discoloration and hyper-pigmentation

• improve tone, smoothness and softness by stimulating your skin’s natural production of hyaluronic acid and collagen

• rejuvenate by correcting your skin’s molecular composition to slow down the aging process

• prevent on-going inflammation to decrease the risk of skin cancer, degeneration and wrinkles

• repair years of sun and environmental damage by supplying missing nutrients to the skin

• protect the skin with the most powerful and effective antioxidants, vitamins, minerals and herbal extracts exclusive to our patent-pending therapy

Some examples of the 28 nutrients in our NaturalLift MD are:

Glucosamine sulfate.

As we age, we lose the ability to manufacture glucosamine sulfate.

As a result, our skin become deficient in hyaluronic acid, the natural cushion that makes a child’s skin soft and smooth.

Glucosamine sulfate is essential for your body to manufacture hyaluronic acid, collagen and elastin fibers
to recreate healthier and younger-looking skin.

Ursolic acid, a natural, easily absorbed substance derived from plants.

Ursolic acid stimulates your cells to produce more collagen which helps reduce the appearance of wrinkles.

In addition, we’ve included in NaturalLift MD the following nutrients in the safest and most effective forms and concentrations proven to effectively reduce wrinkles.

• Resveratrol
• Coenzyme q-10
• DMAE
• Ellagic acid - Pomegranate seed extract
• Grape seed extract
• Niacinamide, which is Vitamin B3
• Superoxide Dismutase
• Green tea extract, with it’s potent and high concentration of Polyphenol EGCG
• Vitamin e is Alpha-Tocopherol and Tocotrienol
• Vitamin a is Retinyl Palmitate and Retinol

We have included these to stop and reverse progressive sun damage from cumulative skin exposure and multiple causes of skin inflammation:

• Gingko Biloba Extract
• Ginsing Extract
• Squalane
• Vitamin D3
• Beta-sitosterol
• Dexpanthenol - Vitamin B5
• and Zinc Oxide

To reduce the appearance of hyper-pigmentation, commonly seen as brown spot in aging skin, as well as to prolong the life of healthy skin cells by as much as 150%, we use a high concentration of magnesium-L ascorbyl phosphate–the safest, most stable in PH neutral form of Vitamin C.

We’ve also included the two most potent skin healing oils known to science in out NaturalLift MD:

Extra virgin olive oil which is high in polyphenols
and borage oil which contains the highest concentration of gamma linolenic acid (GLA).

In addition, our patent-pending liposome nutrient delivery system contains phosphatidylcholine, which maximizes the absorption of both fat and water-soluble nutrients in the depths of your skin.

It’s in the deepest layer of your skin that anti-aging and other beneficial effects take place.

NaturalLift MD is a concentrated treatment that addresses all forms of aging skin as detailed in our book.

Its color is natural.

We do not use any artificial colors, fragrances or paraben preservatives.

NaturalLift MD should be used twice daily for maximum benefits.

In addition, use it before and after surgery for faster healing, before and after in-office procedure such as Derma-abrasion, laser facial peels,  hair, spider vein or tattoo removal and use it throughout the phases of post chemical skin peel healing.

Our medical and scientifically based therapy will enhance and prolong the results of those treatments.

Natural Lift MD is the most powerful anti-aging skin therapy on the market and is available today exclusively through your physician.

Take advantage of the benefits that these power combination of 28 essential nutrients offer and start healing and nourishing your way to a healthier and younger looking skin today.