NaturaLift MD Review Blog

Archive for the ‘prevent cancer’ Category

Ginseng extract blocked carcinogens applied to the skin from causing skin cancer and inflammation. It inhibited the carcinogen TPA from causing an increase in the inflammation- and cancer-causing enzyme, ornithine decarboxylase, and “…expression of cyclooxygenase-2 (COX-2) in TPA-stimulated mouse skin was markedly suppressed. In addition, “… ginseng extract inhibited TPA-stimulated activation of NF-kappaB and extracellular-regulated protein kinase (ERK) in skin and human breast epithelial cells.” Topical ginseng extract also prevented the potent carcinogen TPA from causing multiple skin tumors.

Borage Oil & Gamma Linolenic Acid

Doctors confirmed that the topical application of ginseng extract “… led to the inhibition of TPA-induced expression of COX-2 as well as reducing the production of
prostaglandin E-2. The eukaryotic transcription factor NF-kappaB has been involved in intra-cellular signaling pathways associated with inflammation and carcinogenesis.” The use of the ginseng extract caused “… inactivation of NF-kappaB.” Furthermore, “…when ginseng extract was applied topically prior to TPA, expression and activity of ODC were inhibited dose-dependently.” Ginseng extract also “… inhibited the activation of ERK. Additionally: “… the ginseng extract given prior to each topical dose of TPA markedly lowered the number of papillomas.”

Melanoma, usually appearing as an enlarging black mole, spreads rapidly throughout the body and is lethal. In laboratory tests, ginseng extract was documented to slow the growth of these malignant cells as well as causing their death.

Researchers tested to see if GLA would help the anti-breast cancer drug tamoxifen not only penetrate the skin of patients with breast cancer, but also continue deeper to penetrate into their tumors. Yes, it did: “… [i]t was determined that 2.5 molecules of GLA were associated with each molecule of tamoxifen in the permeation process.”

GLA has itself been shown to be an anti-cancer agent against human breast cancer. This has effects against both estrogen-dependent and estrogen-independent cancer cells. At the beginning of this published article which appeared in a prominent cancer journal, these researchers stated as their basis for undertaking their 2004 study, whose positive outcome was just summarized above: “… [t]he omega-6 polyunsaturated fatty acid gamma linolenic acid (GLA) has raised recent interest as a novel anti-cancer agent as it possesses effective tumorcidal properties while not inducing damage to normal cells or creating harmful side effects.”

Other Environmental Factors

Chlorine & Water. Chlorine is toxic - that’s why it kills germs. It denatures their protein and DNA. You can filter tap water to eliminate the chlorine.

Ozone & Air. Ozone is 1000 time more toxic than chlorine. In the outdoors, ozone is harmless to you because its volume is dissipated in the greater atmosphere. But, having ozone inside the home is another matter.

Never have an ozonator in your house! The best and safest method to sterilize a hot tub uses ozone. Be sure to turn off the ozonator for the hot tub when you turn on the water pumps. Since ozone is not soluble in water, it’s dissipated in less than a minute when the pumps churn 400 gallons of warm (99º-100ºF) water. Stand away during that minute.

Mitigations

Make treatment decisions on the basis of the whole spectrum of interlocking problems; if you’re selective in your choices, the danger is that you’ll remain vulnerable from biochemical gaps in your chosen treatments.

Most doctors and scientists consider natural antioxidants the future method of skin protection from UV-A and UV-B. Unlike natural agents, many synthetic products have toxic side effects. We advise against retinoids, protease inhibitors, and hormones because of their side effects.

Natural antioxidants are safe, non-toxic, and function in many healthful ways to protect the skin from damage. They prevent genetic mutations, and prevent skin cancer at various stages. We discuss these types of natural agents - polyphenols, anthocyanidins, monoterpenes, flavonoids, organosulfides, indoles, vitamins, co-factors, enzymes, and minerals - in detail.

Each nutrient has its own capacity against one or more, but not all, of the
following contributors to skin cancer:

• Damaging DNA while enhancing prolife stage for cell multiplication.
• Excessive growth of the epidermis.
• Depletion of antioxidant systems.
• Induction of the carcinogenic-promoting enzyme ornithine decarboxylase (ODC) - resulting in the absence of abnormal skin cancer development sensations.
• Impairment of the cell’s normal signal transduction pathways to produce normal RNA and cellular proteins and related substances, turning the cell into an alien agent.

Note: Live testing is the bottom line for real effectiveness.

Skin cancer needs to be understood - knowledge of it should not be avoided for fear of the possibility of disfigurement and death. Once you understand the triggering mechanism by which skin cells become cancerous, you’ll be prepar

ed to take the steps needed to stop and even reverse this most common form of cancer.

Ultraviolet Sunlight

According to the American Cancer Society, there will be almost 2 million new cases of basal cell and squamous cell skin carcinoma diagnosed every year in our county. That’s in addition to 47,000 new cases of malignant melanoma annually, causing 7,800 deaths every year. The number of new patients with malignant melanoma is doubling every five years.

“According to the World Cancer Report, skin cancer constitutes approximately 30% of all newly diagnosed cancers in the world, and solar ultraviolet (UV) radiation (particularly, its UVB component; 290-320 nm) is an established cause of approximately 90% of skin cancers.”

The basics of Ultraviolet radiation. The skin is the largest organ, measuring almost 5,000 square inches. This shield is a protective barrier affected by many harmful environmental factors, of which the most damaging is sunlight. Here are some reasons why:

1. The average annual dose of ultraviolet irradiation most Americans typically get each year is 25,000 JÉm2. But when you add the exposure of about 8,000 JÉm2 experienced during a normal vacation in the continental United States, that reaches a very dangerous 33,000 J/m2. That ultraviolet radiation initiates and promotes skin cancer.
2. Our sun is a mass of nuclear explosions. The equivalent of many hydrogen bombs detonate every second; all that radiation explodes out into space at the speed of light. The radiation released by our sun hits exposed skin continuously, like a machine gun barrage.
3. Ultraviolet light is very powerful and more pervasive than we have acknowledged. Ultraviolet rays bombard you from sun-up to sun-down. The
4. maximum harm occurs from 10:00 A.M. until 3:00 P.M. However, any chronic exposure, no matter how small, adds to the cumulative toll, aging the skin and building upon the potential for skin cancer.

Cyclobutane Pyrimidine Dimmers. DNA comprises 30,000 genes located in 23 pairs of chromosomes in human cells, and ultraviolet radiation damages it. UV-B irradiation forms cyclobutane pyrimidine dimmers (CPDs) that specifically and directly damage DNA.

Reactive Oxygen Species. Another, more indirect method, of skin cancer induction occurs when UV-B create reactive oxygen species (ROS). ROSs initiate a series of cascading reactions that damage many large cellular molecules, including DNA.

ROS oxidants created by excessive ultraviolet exposure cause oxidative stress in the skin. Although skin has an elaborate antioxidant defense system, that defense is overwhelmed by cumulative exposure. Lots of low-dose exposure, or one intense dose of ultraviolet radiation, will wipe it out.

Stimulate telomerase. A study from the Department of Dermatology of Case Western Reserve University proved that sunlight causes benign and malignant skin tumors which have up to 45 times more of the cancer enzyme, telomerase, than non-irradiated skin.

As discussed in Appendix A, with every cell division, the ends of each chromosome (telomeres) are chipped away until the chromosome can replicate no longer, causing cell apoptosis. The enzyme telomerase protects and repairs DNA at each cell division. This allows the cancerous cells to divide forever. Without sunlight irradiation, “… [t]elomerase activity was barely detectable.” However,

“… UV-B exposure resulted n a progressive increase in telomerase activity starting from the fourth week of exposure. The increased telomerase activity either persisted or further increased with the increased exposure. In papillomas and carcinomas the enzyme activity was comparable and was 45-fold higher than in the epidermis of control mice.”

Creation of cancer is usually more than just a one-shot event. Multiple toxic enzymes are stimulated by free radicals that activate more harmful enzymes and compounds which, after a varied cascading series of events, eventually cause cancer cells to develop. Other harmful organic compounds manufactured in your body from their free radical-caused cascading series of events aid the spread of cancer cells, and other highly specific organic chemicals cause really dangerous reactions. Therefore, there’s a good opportunity to block the development of cancer and its growth and spread in many molecular chain reaction sites.

Carcinogens are chemicals, molecules, which have been created in the body or enter through diet or skin, and alter cell DNA. Usually, a number of genes are damaged before a specific cell becomes cancerous. This rarely occurs from a single, unlucky, carcinogenic hit.

The body generates dozens of toxic organic compounds after its cells have been attacked by cancer-causing substances or energy. These carcinogens include solar ultraviolet radiation, cigarette smoke, toxic chemicals, and some foods you eat. Even exercise generates free radicals of various types, all of which have the potential to cause cancer.

Many carcinogens cause biochemical changes as they work. Scientists refer to these measurable carcinogenic chemical compounds as markers. Three of the most common are:

1. Ornithine de-carboxylase (ODC)
2. Hydroxy-peroxide production
3. DNA synthetase

Unfortunately, these are too often present in our skin and organs due to environmental factors. Different nutrients have different anti-carcinogen potency. For instance, the very potent carcinogen benzo(a)pyrene (B[a]P) tumor-initiating activity was inhibited as evidenced by a 66% reduction in the number of skin tumors with the topical application of ellagic acid.

As with most anti-oxidants and anti-cancer nutrients, the higher the concentration, the greater the effect. When the benefit realized from the use of a compound increases with higher dosage, that benefit is said to be “…dose-dependent.”

NexDerma® Naturalift MD: Advanced Face Lift Therapy helps block, mitigate, and reverse the effects of ultraviolet radiation on the skin through the ingredients described below.

BHT

“The fact that only a modest, measured protective effect can elicit a dramatic decrease in actinic damage (particularly with regard to cancer) upholds this concept as an important goal.”

This resulted from scientific research conducted by the Photobiology Laboratory on the oral effects of BHT. However, when BHT is ingested with food, it’s very diluted by the time it reaches the skin. Topical applications of BHT were studied in depth. “… BHT offered significant protection (against ultraviolet light mediated sunburn) when applied topically.” Topically applied BHT blocks the cancer causing agent (TPA) from stimulating the cancer-causing enzyme ODC by 80 percent.

“These results demonstrate an early and direct inhibition of TPA-induced ODC activity by lipophilic phenolic antioxidants (including BHT) and suggest a role for reactive oxygen and/or free radical species in tumor promotion.”

CoenzymeQ-10 (Ubiquinone)

It’s essential to avoid the sun. And, never forget to apply a skin protective therapy containing the correct concentration of coenzyme Q-10 and the natural forms of vitamin E (alpha, beta, gamma, and delta tocopherols, and tocotrienols).

Doctors and skin research scientists report that:

“Coenzyme Q-10, or Ubiquinone, is a nutrient - a vitamin-like substance which plays a crucial role in the generation of cellular energy and in free radical scavenging in the human body. After the age of 35 to 40, the organism (YOU) begins to lose its ability to synthesize CoQ-10 from food, and its deficiency develops. Aging, poor eating habits, stress and infection - they will all affect your ability to provide adequate amounts of CoQ-10.”

Extra-Virgin Olive Oil

Extra virgin olive oil is a potent antioxidant. When applied before exposure to UV-B, experiments have demonstrated it helps protect the skin from developing cancer. This result was also documented when extra virgin olive oil was applied to the skin after UV-B exposure. Dermatologists conducting the study reported:

“Mice that received extra virgin olive oil after UV-B exposure showed significantly lower numbers of tumors per mouse than those in the UV-B control group throughout the experimental period.”

Another study reported that:

“…there were lower levels of 8-hydroxy-2-deoxyguanosine (8-OHdG: a carcinogenic agent) in epidermal nuclei. These results indicate that extra virgin olive oil topically applied after UV-B exposure can effectively reduce UV-B-induced murine skin tumors (by 62%), possibly via its antioxidant effects in reducing DNA damage by reactive oxygen species.”

“In this study the effects of hydroxytyrosol (DOPET), the major antioxidant compound present in extra virgin olive oil on UV-A induced cell damages, have been investigated using human melanoma cells.”

Further: “… [t]hese protective effects are dose dependent.”

Doctors studied the effect of extra virgin olive oil topically-applied to the skin before each of multiple doses of x-rays: “… [t]he data indicated a definite radioprotective effect of the topical administration of extra virgin olive oil.”

Authors of a related article pointed out that: “… regular olive oil neither retarded nor reduced skin cancer formation in UV-irradiated mice. Our results suggest that daily topical use of extra virgin olive oil after sunbathing may delay and reduce UV-induced skin cancer development in human skin, possibly by decreasing reactive oxygen species-induced 8-OHdG which is responsible for gene mutation.”130 They also noted that: “…[a]ntioxidants vitamin E and epigallocatechin-3-gallate (EGCG) extracted from green tea, applied topically to the skin, delayed the onset of UV-induced skin cancer in mice.”

Ginkgo Biloba Extract

Applied to the skin, this compound is very protective against the free radical
generation caused by UV-B irradiation. Ginkgo biloba extract is both protective against ultraviolet radiation and therapeutic, even when applied after exposure. When tested orally, ginkgo biloba extract protected skin from ultraviolet radiation better than orally-ingested beta carotene and vitamin E. Ginkgo biloba extract controls stress-induced free radicals.

Ginseng Extract (Panax)

Ginseng extract:

“…significantly reduced ultraviolet-B induced cell death and protected human keratinocytes from apoptosis caused by ultraviolet-B irradiation.” Biochemically it “…prevented ultraviolet-B-induced cleavage of poly (ADP-ribose) polymerase (a critical enzyme) in keratinocytes. In search of the molecular mechanism responsible for the anti-apoptotic effect of the ginseng extract, we find that protection from ultraviolet-B-induced apoptosis is tightly correlated with the ginseng extract mediated inhibition of ultraviolet-B-induced down-regulation (decreasing the genetic molecular activity) of Bcl-2 (toxic compound) and Brn-3a (toxic compound) expression.”

Green Tea Extract & EGCG

Since many of the toxic reactions causing aging in cells were accelerated by a combination of UV-A and/or UV-B plus topically applied toxic chemicals, experiments were performed to see how effectively EGCG prevents photoaging. The results were very impressive: from excellent to good, depending on doses of sunlight, toxic chemical and type used, and the amount of EGCG applied. Many documented both anti-cancer and anti-photoaging effects of EGCG.

EGCG protects the extracellular matrix (ECM) from oxidative stress from ultraviolet radiation.

“EGCG can reverse the ECM degradation induced by UV even with a topical application of a practical-use concentration. In particular, EGCG proved to be much more effective in ROS-related conditions, such as UVA exposure.”

Magnesium-L-Ascorbyl-Phosphate (Vitamin C)

Magnesium-L-ascorbyl-phosphate, a form of vitamin C (ascorbic acid), is absorbed into the skin where it is continuously and safely converted into ascorbic acid. It is not acidic like l-ascorbic acid, which stings and burns skin and is a serious danger to the eyes.

“Pretreatment with magnesium-L-ascorbyl-phosphate significantly prevented such photo-damage as sunburn cell formation, DNA fragmentation and lipid (fatty compounds such as cell membranes) peroxidation which were caused by a single dose of UVB irradiation. These results [of this study] suggest that the protective effect of magnesium-L-ascorbyl-phosphate on UVB-induced cutaneous damage is due to the maintenance of a normal ascorbic acid level by conversion of magnesium-L-ascorbyl-phosphate to ascorbic acid in skin tissue.”

Can topically-applied ascorbic acid protect skin against UV-B radiation? No:

“In this study, AsA (also known as ascorbic acid) could not inhibit cytotoxicity, but AA-2P (Ascorbyl phosphate) and AA-2G was able to cancel the harmful effect of UV-B when treated at high levels of 0.5-5 mM.”

Magnesium-L-ascorbyl-2-phosphate is a potent antioxidant, protecting the skin from ultraviolet sunlight.

“…after acute and chronic exposure to UVB irradiation … administration of magnesium-L-ascorbyl-2-phosphate immediately after acute exposure to 15kJ/m¹ of UVB significantly prevented increases of UVB-induced lipid peroxidation in skin. Administration of magnesium-L-ascorbyl-2-phosphate immediately after each exposure significantly delayed skin tumor formation and hyperplasia induced by chronic exposure to UVB. Magnesium-L-ascorbyl-2-phosphate, once converted in the skin to ascorbic acid, exhibits such inhibitory effects by scavenging hydroxyl and lipid radicals generated as a direct or indirect result of UVB exposure.”

Note: Ascorbyl palmitate (C-ester) is toxic to skin cells when applied topically and exposed to sunlight, as noted by the prestigious Mayo Clinic.

Resveratrol

Resveratrol is an antioxidant more powerful than vitamin E. It was compared to seven other well known antioxidants that are used to preserve food, including vitamin E. Resveratrol was very potent in stopping lipid peroxidation. It was also good at scavenging the hydroxyl-activated ion (OH), beating out vitamin E in both essential categories of antioxidant function. But neither was effective against hydrogen peroxide (H2O2). That’s why the correct combinations of potent antioxidants are required for optimal protection.

Resveratrol applied topically to the skin is photo-chemo-protective against acute and chronic sunlight damage, decreases tumor-causing enzymes, and protects lipids and related critical substances.

Doctors at the University of Wisconsin Department of Dermatology studied the chemopreventive effects of resveratrol against UV-B radiation-mediated skin tumorigenesis. They concluded: “… [t]he topical application of skin with Resveratrol resulted in a highly significant 1) inhibition in tumor incidence, and 2) delay in the onset of tumorigenesis. Interestingly, the post-treatment of Resveratrol was found to impart equal protection
than the pretreatment; suggesting that Resveratrol-mediated responses may not be sunscreen effects.”

Superoxide Dismutase

Doctors at the Jefferson Medical College Department of Dermatology and Cutaneous Biology showed the power of superoxide dismutase “… to protect against ultraviolet-A and ultraviolet-B induced damage. The ability of superoxide dismutase to prevent radiation-induced elastin promoter activation was determined in vivo. Superoxide dismutase (analog Temprol) provided over 50% protection against ultraviolet B and over 70% protection against ultraviolet A.” They recommended this agent “… to prevent cutaneous aging.”

A study of comparing biopsies of sun-damaged skin of young volunteers with biopsies of undamaged control sites:

“In photo-aged skin, a significant depletion of antioxidant enzyme superoxide dismutase expression was observed within the stratum corneum and in the epidermis. Importantly, an accumulation of oxidatively modified proteins was found specifically within the upper dermis.”

Skin cells were subjected to sunlight, and volunteers were also subjected to 10 days of sunlight.

“Exposures of keratinocytes and fibroblasts to ultraviolet B, ultraviolet A, and hydrogen peroxide led to a dose-dependent protein oxidation and thus confirmed in vivo results. In conclusion, the correlation between photo-damage and protein oxidation was demonstrated for the first time, which hence may be a relevant pathophysiologic factor in photo-aging.”

This directly relates to how oxidative stress hastens cellular death: “… [w]hen the cells are grown under conditions of oxidative stress, cellular longevity is markedly shortened.” This occurs despite the Hayflick Limit, where the “… human maximal lifespan can be equal to about 145 years.”

Titanium Dioxide

Only titanium dioxide (Ti02) offers protection against all varieties of ultraviolet radiation. Fortunately, it also provides 80% to 100% protection against blue light.

It was considered that the inorganic metal oxides such as titanium dioxide and zinc oxide only reflected sunlight. But, “… [t]his is not the case with modern micronized forms of metal oxides. It has been shown that both zinc oxide and titanium dioxide mobilize electrons within their atomic structure while absorbing UV radiation.” They reflect and neutralize UV by absorbing the energy, as sun blocks should. These researchers, and many others, concluded that titanium dioxide, as well as zinc oxide, “…are stable, non-toxic, and safe, and they act as highly efficient UV attenuators.”

In a series of exquisite experiments, researchers used very fine particulate titanium dioxide at concentrations of 1%, 5%, and 10% against three increasingly higher doses of UV-B radiation. They also compared these results to the well known sunscreens of para-aminobenzoic acid (PABA) and urocanic acid, each at a 1% concentration. The control was plain petrolatum. They determined the effect of UV-B on the DNA of living skin. The results showed that both PABA and the urocanic acid provided poor protection, while titanium dioxide gave 100% protection at the 1% solution level. DNA was unchanged from the non-irradiated controls. The protection achieved by a 5% concentration was the same as with 1%, but was effective against double the level of UV-B radiation.

Vitamin A

A major study evaluating the effectiveness of retinaldehyde (a safe and effective topical precursor of vitamin A) found that:

“…UV-A exposure induced significant alterations of collagen and elastic fibers. In all UV-A exposed and then retinaldehyde-treated skin specimens, collagen and elastic fibers were restored to the level of non-exposed skin.”

Vitamin D3 (Cholecalciferol)

In an extensive study, scientists applied the active form of vitamin D3 (cholecalciferol) to the exposed skin of albino hairless mice before each UV exposure. Then the mice were exposed to ultraviolet radiation at a moderate strength (11 J/cm¹) for two hours a day, five days per week, for 20 weeks. Wrinkles formed in the untreated skin. This was documented in photographs. Microscopically, there was a loss of fat cells and an increase of fibrous tissue. No wrinkles were seen in skin topically treated with cholecalciferol; microscopically, the skin remained normal.

“…[V]itamin D3 is efficacious against fibrosis (scar tissue formation) in the lower dermis induced by chronic solar-stimulating UV irradiation. The application of vitamin D3 on the dorsal skin prior to irradiation prevented the disappearance of adipocytes. Taken together, solar-stimulating UV irradiation effects on the proliferation and differentiation of skin cells including adipocytes, fibroblasts, and keratinocytes, resulted in hyperplasia (thickening) of epidermis and fibrosis (scar tissue formation) of adipose tissue. Cholecalciferol prevents these phenomena.”

Vitamin E (Natural Alpha Tocopherol and Tocotrienols)

The natural forms of vitamin E (alpha tocopherol and tocotrienols) are fat-soluble antioxidants that scavenge many free radicals, including lipid peroxyl radicals. Vitamin E absorbs only UV-B, not UV-A (vitamin A absorbs both UV-B and UV-A). However, the stratum corneum is very depleted of alpha-tocopherol following a single acute exposure to either UV-A or UV-B, or both. The destruction of the surface-level alpha tocopherol is also caused by the secondary effects of ultraviolet irradiation that generates free radicals.

Vitamin E has been demonstrated to decrease the severity of UV-caused skin wrinkling by 75% and also significantly decreases erythema and edema from UV injury.

Zinc Oxide

Zinc helps prevent UV-B cell apoptosis, even when it is used after exposure. Zinc can also protect fibroblast cells, allowing them to resist the oxidative stress from both UV-A and UV-B.

A zinc solution was tested to see if it protects skin from ultraviolet light so intense that it would be two times the minimal dose needed to cause sunburn. It was applied topically either five days in a row or one time two hours before exposure. Both methods reduced the percentage of sunburn cells.

In other experiments, researchers also tested the topical use of zinc to see what, if any, effect it would have when applied topically one or two hours after ultraviolet light exposure. In this, zinc even offered 25% protection when applied as late as one hour after ultraviolet exposure, but none when initially applied two hours after exposure. The zinc oxide in NexDerma® Naturalift MD: Advanced Face Lift Therapy provides continuing protection.

Free radicals are toxic molecules resulting from exposure to ultraviolet radiation. Oxygen, the essential element to life, is damaged and contributes to the creation of reactive oxygen species. Hydroxy ions (-OH) abound, missing an electron that, in an attempt to become whole again, they create holes in other molecules.

Free radicals can oxidize fatty molecules, a process known as lipid peroxidation. That’s a catastrophe because the cell needs a functional plasma membrane to sustain life.

It is through this membrane that nutrients and oxygen needed for life and body function pass. Most waste produced by the cel s, including carbon dioxide pass through each cell’s membrane, and into the microscopic capillaries. From there, they enter the main bloodstream to be removed by the kidneys, liver, and lungs. The remaining waste that passes through the cel membrane enters the fluid between the cells (interstitial fluid) and from there into the lymphatic channels where they eventually enter the bloodstream in the upper chest.

But, when the membrane is damaged by lipid peroxidation, the cell begins to age rapidly and die. This membrane is composed of two layers of fatty substances, which, when oxidized, fail to function. These oxidation bullets” attack at random, but the more unblocked sunlight hitting the skin, the more free radicals are generated in all layers of the skin.

Note: Free radicals are generated not only by ultraviolet sunlight: weather, and other pollutants such as smoke, chlorine, harsh detergents, and cosmetics also create them.
Reactive Oxygen Species

Studies have clearly shown that reactive oxygen species, such as superoxide anion (O2-), hydroxyl radical (-OH), and hydrogen peroxide (H2O2), are responsible for ultraviolet-induced oxidative damage. Reactive oxygen species also directly contribute to the cause of skin cancers, photoaging, and many skin and inflammatory disorders.

Reactive oxygen species damage cell membranes by the peroxidation of fatty acids in the phospholipid structure of the membrane. Unfortunately, the process doesn’t stop there. Peroxidation forms lipid peroxide radicals, lipid hydroperoxides, and other lipid fragmentation products, which are active oxidizing agents. This chain reaction, in which electrons are removed from lipids such as cell membrane phospho-lipids, give rise to more lipid radicals. As long as there is oxygen in the system, this chain reaction will continue and lipid peroxides will continue to accumulate until they are reduced by antioxidants in the skin.

Free radical reactivity generates a chain reaction of many free radical species production, enhancing skin aging and skin cancer.

Loss of Fat-Soluble Nutrients

The top of the skin is covered by natural protective secretions called skin surface lipids (SSL). These are: “… a very complex mixture of sebum mixed with small amounts of epidermal lipids, which mantle the human epidermis, thus representing the outermost protection of the body against oxidative insults.” The body of a well-nourished, healthy, and non-stressed child or an older person may make an adequate amount of coenzyme Q-10. However, exposure to four times the amount of sunlight that causes just some redness of the skin depletes protective SSLs by 70% of coenzyme Q-10 and 84% of vitamin E.

Cumulative Ultraviolet Light Exposure

Sub-chronic sunlight (UV-A and UV-B radiation) exposure is the sum of what you’ve been getting all your life. It does not result in sunburn or a noticeable tan, but it wreaks havoc on the skin. In 2002, scientists finally examined this problem histologically and found these harmful effects:

• After just one month, there was obvious epidermal hyperplasia (thickening of the outer layer of the skin). In three months, that progressed to “… epidermal thickening and formation of epidermal ingrowths projecting into the dermis.”
• The “… keratinocytes were somewhat pleomorphic.” These keratinocytes developed “… cytoplasmic projections which migrated into the dermis.” What should have been a well-defined junction between the epidermis and dermis, the basement membrane,” began to “… disappear along with the development of edema spreading from the upper dermis to the epidermis.”
• Furthermore, “… [i]n the dermis, in addition to edema, fibroblast proliferation and mast cell infiltration progressed with time, and degranulation was obvious at two and three months. In the upper dermis, especially beneath the epidermis, decrease in diameter and disintegration of collagen fibrils (the main structural protein compound of the skin) were observed.”

Dimethicone

When tested against a chemical known to cause irritant contact dermatitis (sodium lauryl sulfate), dermatologists at the University of California School of Medicine stated:

“This study demonstrated that appropriate dimethicone skin protection products may provide certain benefits from surfactant irritant contact dermatitis. The skin protection lotion may be used to prevent irritant contact dermatitis in home or work environments, where skin irritants may induce dermatitis or eczema.”

Dexpanthenol (Vitamin B5)

Many medical professionals suffer from irritant-caused dermatitis or from a contact dermatitis (such as a reaction to poison ivy). 38% of 262 subjects had severe skin stress, 31% had severely dry skin, and 17% had dermatological diseases of the hands. After just three weeks of topical application of dexpanthenol:

• 79% rated their skin condition as improved or normal.
• 95% rated their results as good or very good compared with the awful condition of their skin before beginning treatment, and against problems experienced with other forms of treatment.

Contact allergy from dexpanthenol is very rare, and the FDA recognizes dexpanthenol as Generally Recognized As Safe. Dexpanthenol has been referred to as atoxic; in fact, it has been used to treat dry eyes and to aid healing corneal ulcers that often result from the overuse of contact lenses.

Ginkgo Biloba Extract

Ginkgo biloba extract has been shown to be very non-allergenic, even in highly allergic patients. Furthermore, it has demonstrated strong anti-allergy activity in patients whose skin is highly reactive to contact dermatitis. In tests, ginkgo biloba proved to be an anti-irritant substance for the skin. Among many substances tested for their anti-irritant protection of skin, ginkgo biloba was among the few noted to be beneficial.

Ginkgo biloba extract stimulates fibroblast cells to secrete healing collagen. In addition to enhancing the amount of collagen in aging skin, it is also anti-inflammatory. Other positive benefits of ginkgo biloba include the fact that it:

• Stops the loss of skin pigmentation and aids re-pigmentation in cases of vitiligo.
• Stimulates skin circulation.
• Increases blood flow to the brain in patients with demonstrated arteriosclerotic lesions.
• Demonstrates positive benefits in patients suffering from polyneuropathies.

Zinc Oxide

The body requires zinc in a salt form, which is a form of zinc (zinc +2) attached to an ion. Zinc salts, unlike other metal salts of nickel and chromium, do not cause contact allergy as noted in the very sensitive local lymph node assay test for contact allergens.

Disease Free Skin with NaturaLift MD

Dexpanthenol (Vitamin B5)

Let’s look at the results of a study involving 483 subjects who had the following significant skin diseases:

• Atopic dermatitis
• Ichthyosis (thick, scaly skin)
• Psoriasis, or contact dermatitis

Symptoms included:

• Dryness of the skin
• Roughness
• Scaling
• Itchiness (pruritus)
• Redness (erythema), erosions
• Fissures

All subjects recorded greater than 80% improvement from topical treatment. And where the symptoms were dryness or desquamation (loss of surface skin layers), their results were even better: greater than 90%. And considering how fragile and diseased their skin was, there was local irritation in only 1.9% of these 483 subjects.

Niacinamide (Vitamin B3)

Skin diseases helped by the topical application of niacinamide include psoriasis, rosacea, pityriasis ruba pilaris, bullous pemphigoid, and isoniazid-induced (an anti-tuberculosis drug)
pellagra-like skin eruptions.

Superoxide Dismutase

In addition to all the benefits from topical superoxide dismutase, in 2004, doctors at the University of Sao Paulo (Brazil) Faculty of Pharmaceutical Science reported that: “… [t]opical formulations with superoxide dismutase, a scavenger of superoxide radicals, have proved to be effective against some skin diseases.”

Vitamin D3

Psoriasis. Scientists discovered that the active forms of vitamin D (1,25 dihydroxyvitamin D, also known as 1,25(OH)2D3 and cholecalciferol) are physiological regulators of cell proliferation and differentiation. The active forms of vitamin D are therapeutic for psoriasis, a skin disease. that causes the production of an excessive number of epidermal keratinocytes.

Eczema. “The treatment of hyperkeratotic palmoplantar eczema is notoriously difficult. A considerable number of patients do not or only partially respond to the current treatments such as topical corticosteroids, topical keratolytics, or PUVA therapy.”

In this study, five patients with hyperkeratotic palmoplantar eczema were treated with topical vitamin D3 derivatives.

“…The lesions almost disappeared after 2 to 8 weeks of treatment in four patients and extremely improved with a seven week treatment in one patient. No adverse effect was observed during or after the treatment. The results suggest that vitamin D3 derivatives offer a safe, effective alternative form of treatment for recalcitrant hyperkeratotic palmoplantar eczema.”

“The choice of vehicle is an important consideration in acne therapy. Because the epidermal barrier may be impaired by both the underlying disorder and the use of some topical treatments for acne, vehicle formulations that minimize barrier impairment, help to restore barrier function, and limit signs and symptoms of skin irritation are valuable components of acne therapy, especially early in the course of treatment or with combination regimens.

…[E]mollient dimethicone has been shown to improve skin tolerability and overall patient preference compared with the same active ingredients formulated without the special additives that provide moisturization.”

Doctors at the University of Louisville School of Medicine performed a study using dimethicone on subjects with “… chronic hand dermatitis for at least 12 months, felt to be either allergic, irritant, or combined in nature. Topical corticosteroid usage was reduced 54%. No adverse effects were noted. 70% had improved over the course of the study. Dimethicone “… greatly or moderately improved chronic hand dermatitis in a sizable number of individuals with previously uncontrolled dermatitis despite continuing in their regular occupation.”

Niacinamide (Vitamin B3)

This nutrient has very strong anti-inflammatory properties which cause a significant improvement in acne. By reducing inflammation, niacinamide decreases leukocyte peroxidase enzymes that lead to localized skin damage and thereby improves the appearance of the skin. It helps suppress inflammation caused by white blood cells when triggered by antigens.

Along with other all natural ingredients, Vitamin B3 and Dimethicone is proven to improve skin acne, by reducing inflammation and hastening the healing process of your skin.

Coenzyme Q-10 (Ubiquinone)

Fifteen German doctors and scientists stated in a recently published study about coenzyme Q-10:

“We have investigated whether topical application CoQ-10 has the beneficial effect of preventing photoaging. We are able to demonstrate that CoQ-10 penetrated into the viable layers of the epidermis and reduced the level of oxidation measured by weak photon emission. Furthermore, a reduction in wrinkle depth following CoQ-10 application was also shown. CoQ-10 was determined to be effective against UV-A mediated oxidative stress in human keratinocytes(Cells in the primary outer layer of our epidermis.) in terms of thiol depletion, activation of specific phosphotyrosine kinases(A class of enzymes.) and prevention of oxidative DNA damage. CoQ-10 was also able to significantly suppress the expression of collagenase(The harmful enzyme that dissolves the skin’s collagen.) in human dermal fibroblasts following UV-A irradiation. These results indicate that CoQ-10 has the efficacy to prevent many of the detrimental effects
of photoaging.”

Here’s how ten skin specialists described the results of their skin studies using coenzyme Q-10:

“We demonstrated a diminished resistance in keratinocytes of old donors against UV irradiation. This reduced epidermal resistance against oxidative stressors, i.e.: UV irradiation, can be improved by topical application of CoQ-10.”

They also stated:

“Our in vivo investigations shows that wrinkles around the region of the eyes could be reduced by long-term application of CoQ-10.”

Dosage is critical for best results. Doctors performed experiments to evaluate the penetration of coenzyme Q-10 in the skin. They stated: “… [c]oenzyme Q-10 skin levels were found to be directly related to the concentration employed and the contact time.” In another study which evaluated topical application and skin levels CoQ-10, researchers observed: “… high concentrations of CoQ-10 may be achieved in the skin by topical treatment.”

In another experiment, researchers used only a 0.05% concentration of topical coenzyme Q-10, and achieved: “… a significant increase that peaked after 60 days.” However, this increase was only in the sebum(The fatty substance secreted on top of the skin). There was no significant concentration in the stratum corneum(The outermost epidermis layer).

Therefore, concentration is very important. That’s why we based ours on science: to give you the most effective concentration available. As the pervious authors stated: “Coenzyme Q-10 levels were found to be directly related to the concentrations employed and the contact time…” That’s why we use a high concentration and recommend application at least twice a day to maximize the affect of our optimally formulated Therapy.

Both come from the same plant: black tea is aged; green tea is not. During the aging process, oxidation damages and changes the form of some of the active compounds in tea. Both have anti-cancer and anti-aging properties, but green tea is better for you.

Green tea and its major compound (EGCG) have been studied in hundreds of published research papers. While black tea has undergone fewer studies, it has also attained positive results. Black tea contains EGCG, but has a higher content of the aflavone gallate. Both inhibit carcinogens causing cancer, including the growth of pancreatic adenocarcinoma cel s at 95% inhibition and prostate cancer cells, also at 95% inhibition of growth. However, the numerous carcinogens tested for nutrient anti-cancer activity are far exceeded by green tea, and specifically by EGCG published studies.

• EGCG is effective therapy for cervical herpes virus infection.
• EGCG taken either orally and/or applied vaginally on the cervix has a 69% positive response rate against the herpes virus infection.
• EGCG renews aged skin cells, including healthy DNA synthesis 37 times!

When EGCG was applied to skin, it reversed age-related thinning. Furthermore, it protected skin cells from excessive scarring, at the same time protecting the stability of collagen in skin. EGCG protects cells against arsenic poisoning and protects the skin’s immune system; it is easily absorbed by skin. EGCG also has been shown to have an anti-allergy effect.

Skin cancer is the most common type of cancer with almost two million Americans  diagnosed every year.  Normal skin cells die every few weeks, replaced by younger cells produced by their parent cells. And they stay put. Cancer cells divide and replicate every few days, and do so continually. Furthermore, they spread by pushing their way into adjacent normal skin by dissolving the intervening tissue, and penetrate deeper into fat and muscle. The more malignant forms of skin cancer metastasize and spread to distant places throughout your body, eventually killing you by damaging vital organs.

Since it takes more than one injured gene to cause a skin cell to turn cancerous, as you will read, the nutrients in NexDerma® Naturalift MD: Advanced Face Lift Therapy help stabilize pre-cancerous cells. Eventually, abnormal cells die without passing on their altered genetic state. Nutrients in our product have been scientifically demonstrated to heal damaged DNA, too.

Wrinkles, cancer, coronary artery disease, and aging have much in common. The body is a well balanced mechanism that, unlike machines, is capable of healing. Some nutrients cause imbalance while others stimulate and aid healing.

Agents, such as ultraviolet sunlight and chemicals, cause cancer by stimulating dangerous components of our cells to proliferate, altering healthy DNA. These unfortunate and preventable mutations produce cel ular enzymes and related organic compounds that allow injured cells to keep growing and spreading. Oncologists and scientists call the changes of normal to cancer cells: initiation,” followed by promotion” and progression.”

No one catches” skin cancer. When DNA has been severely altered, the brakes” on the
reasonable division of that cell, and all that come from its replications, will go unchecked (see Appendix A).

Creation of cancer is usually more than just a one-shot event. Multiple toxic enzymes are stimulated by free radicals that activate more harmful enzymes and compounds which, after a varied cascading series of events, eventually cause cancer cells to develop. Other harmful organic compounds manufactured in your body from their free radical-caused cascading series of events aid the spread of cancer cells, and other highly specific organic chemicals cause really dangerous reactions. Therefore, there’s a good opportunity to block the development of cancer and its growth and spread in many molecular chain reaction sites.

Carcinogens are chemicals, molecules, which have been created in the body or enter through diet or skin, and alter cell DNA. Usually, a number of genes are damaged before a specific cell becomes cancerous. This rarely occurs from a single, unlucky, carcinogenic hit.

The body generates dozens of toxic organic compounds after its cells have been attacked by cancer-causing substances or energy. These carcinogens include solar ultraviolet radiation, cigarette smoke, toxic chemicals, and some foods you eat. Even exercise generates free radicals of various types, all of which have the potential to cause cancer.

Naturalift MD: Advanced Face Lift Therapy helps mitigate and reverse the effects of skin cancers through the actions of the ingredients described below. These facts underpin our research and product lines:

• Scientists have discovered many bad actors” within cells that cause cancer and aging.
• They have also identified specific organic compounds and minerals that block the bad players from causing harm.

Beta-sitosterol. Among many substances tested for the ability to protect the skin, beta-sitosterol was among the few noted to offer this healing benefit. Beta-sitosterol was also shown to be a potent anti-inflammatory agent by blocking the COX-2 (CycloOXygenase-2) enzyme, which causes inflammation. Beta-sitosterol was confirmed to specifically inhibit the function of this inflammation-causing enzyme in the skin, and at a concentration even less than we suggest (we recommend a higher concentration because of all its other benefits).

Ellagic Acid that came from Pomegranate Seed Extract has proven itself again and again to be a potent topically-applied anti-cancer nutrient. In 2005, doctors at the prestigious University of California Department of Radiation Oncology determined that ellagic acid is one of the most effective compounds they tested of twenty against cancer.Ginseng Extract (Panax)

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