NaturaLift MD Review Blog

Dynamic Wrinkle Injections like Botox, Dysport, and Myobloc are the three FDA-approved drugs. All three paralyze the facial muscles: they are derived from the poison excreted by the bacteria clostridium botulinum. Paralyzed facial muscles atrophy and can eventually cause loss of texture and increased sagging.

In adults, botulism is caused by the oral ingestion of the preformed toxin found in contaminated food. In infants, this paralyzing disease is usually caused by the ingestion of live bacteria, most often from non-pasteurized honey. In both adults and children, botulism causes progressive paralysis and results in death from paralysis of the respiratory muscles, unless the victim receives ventilator support in an Intensive Care Unit.

The correct topical nutrients in their optimal concentrations can prevent and heal the many diverse conditions which damage and age your skin. NexDerma® Naturalift MD: Advanced Face Lift Therapy helps mitigate and reverse the effects of skin problems using the ingredients described below.

How The Naturalift MD: Advanced Face Lift Therapy Dramatically Reduces Wrinkles  In Your Skin

Coenzyme Q-10 (Ubiquinone).  Fifteen German doctors and scientists stated in a recently published study about coenzyme Q-10:

“We have investigated whether topical application CoQ-10 has the beneficial effect of preventing photoaging. We are able to demonstrate that CoQ-10 penetrated into the viable layers of the epidermis and reduced the level of oxidation measured by weak photon emission. Furthermore, a reduction in wrinkle depth following CoQ-10 application was also shown. CoQ-10 was determined to be effective against UV-A mediated oxidative stress in human keratinocytes(Cells in the primary outer layer of our epidermis.) in terms of thiol depletion, activation of specific phosphotyrosine kinases(A class of enzymes.) and prevention of oxidative DNA damage. CoQ-10 was also able to significantly suppress the expression of collagenase(The harmful enzyme that dissolves the skin’s collagen.) in human dermal fibroblasts following UV-A irradiation. These results indicate that CoQ-10 has the efficacy to prevent many of the detrimental effects of photoaging.”

Here’s how ten skin specialists described the results of their skin studies using coenzyme Q-10:

“We demonstrated a diminished resistance in keratinocytes of old donors against UV irradiation. This reduced epidermal resistance against oxidative stressors, i.e.: UV irradiation, can be improved by topical application of CoQ-10.”  They also stated “Our in vivo investigations shows that wrinkles around the region of the eyes could be reduced by long-term application of CoQ-10.”

Dosage is critical for best results. Doctors performed experiments to evaluate the penetration of coenzyme Q-10 in the skin. They stated: “… [c]oenzyme Q-10 skin levels were found to be directly related to the concentration employed and the contact time.” In another study which evaluated topical application and skin levels CoQ-10, researchers observed: “… high concentrations of CoQ-10 may be achieved in the skin by topical treatment.”

In another experiment, researchers used only a 0.05% concentration of topical coenzyme Q-10, and achieved: “… a significant increase that peaked after 60 days.” However, this increase was only in the sebum(The fatty substance secreted on top of the skin). There was no significant concentration in the stratum corneum(The outermost epidermis layer).

Therefore, concentration is very important. That’s why we based ours on science: to give you the most effective concentration available. As the pervious authors stated: “Coenzyme Q-10 levels were found to be directly related to the concentrations employed and the contact time…” That’s why we use a high concentration and recommend application at least twice a day to maximize the affect of our optimally formulated Therapy.

DMAE.  A 2005 randomized clinical study published in the prestigious American Journal of Dermatology found that topical use of DMAE:

“…applied daily for 16 weeks has been shown to be safe and efficacious in the mitigation of forehead lines and periorbital(Periorbital=around the eyes) fine wrinkles, and in improving lip shape and fullness and the overall appearance of aging skin. These effects did not regress during a 2-week cessation of application. Beneficial trends were noted in the appearance of course wrinkles, under-eye dark circles, nasolabial folds, sagging neck skin, and neck firmness. Application was noted to be well tolerated, with no difference in the incidence of erythema, peeling, dryness, itching, burning or stinging between DMAE and placebo groups. Long-term application of DMAE for up to one year was associated with a good safety profile. The acute skin-firming effects of DMAE have been confirmed by quantitative measures of cutaneous tensile strength. DMAE is a moderately active anti-inflammatory agent.”

Ginseng Extract (Panax).  Topically-applied ginseng extract markedly reduced inflammation. As reported in 2005, ginseng is a herb that contains compounds “… that possesses anti-tumor effects, including inhibition of invasion, metastasis, and angiogenesis, and induction tumor cell apoptosis. Tumor promotion often accompanies an elevated ornithine decarboxylase (ODC) activity, acute inflammation and induction ofcyclooxygenase-2 (COX-2) activity.”

Glucosamine Sulfate.  The most vivid example of age reversal in the skin is achieved using topical glucosamine sulfate: obvious wrinkles are erased day by day. Most people begin to see a real change within one week of using NexDerma® Naturalift MD: Advanced Face Lift Therapy twice daily. For more information, see Appendix B.  Glucosamine sulfate is required to manufacture hyaluronic acid; production markedly diminishes in adults. As a result, we lose the look and texture of the skin of our youth, but this is reversible.

Grape Seed Extract. Grape seed extract protects the microscopic blood vessels inside the skin, and thereby helps to prevent wrinkles:

“Besides erythema and sunburn reactions, UVB stress can promote erythrocyte extravasation from skin capillaries and hemolysis, and photo-sensitized hemoglobin can in turn lead to an overload of free radicals in dermis (skin) which exacerbates photo-damage. Grape seed procyanidins dose-dependently delay the onset of hemolysis. EGCG was less potent. Since grape seed procyanidins inhibit the formation of phospholipid hydroperoxides of the inner and outer layers of the red blood cell membrane, their strong anti-lipo-peroxidant activity, may maintain in vivo the integrity of red blood cells in sub-epidermal capillaries and effectively counteract in dermis the onset/exacerbation of the UVB-induced skin photo-damage.”

Green Tea Extract & EGCG.  EGCG significantly reduces and inhibits inflammation of the skin.

Green tea reverses the aging process in epidermal cells and reduces tumor growth, too. The topical use of green tea extract with EGCG significantly increases the metabolic level of keratinocytes. Here’s what doctors from medical colleges in the US and Japan said in 2003:

“The most abundant green tea polyphenol EpigalloCatechin-3-Gallate (EGCG), was found to induce differential effects between tumor cells and normal cells.”

EGCG stimulates only non-cancerous cells. The report also stated: “… [a]ged keratinocytes, which exhibited low basal cellular activities after culturing in growth medium for up to 25 days, renewed DNA synthesis and activated succinate dehydrogenase up to 37-fold upon exposure to either EGCG or the polyphenols.”

Niacinamide (Vitamin B3).  Aging skin produces less of the fatty substance, ceramide, that helps the keratinocytes serve as the normal barrier that prevents water loss. Niacinamide stimulates ceramide synthesis, helping reduce the appearance of aging.

“Niacinamide is a more effective moisturizer than white petrolatum on atopic dry skin, and may be used as a treatment in atopic dermatitis.”

A clinical study of topically applied niacinamide in July of 2005 found:  “Analyses of the data revealed a variety of significant skin appearance improvement effects for topical Niacinamide: reductions in fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness. In addition, elasticity was improved. …In addition to previously observed benefits for topical Niacinamide, additional effects were identified.”

In 2005, dermatologists at the University of Cincinnati performed a clinical human study that clearly demonstrated the power of niacinamide to erase facial hyperpigmented skin lesions.

Resveratrol. “… decreases the proliferation of skin fibroblast cells, to decrease scar tissue and prominent wrinkles.”

Superoxide Dismutase. Dermatologists at the University of Cologne stated:

“Reactive oxygen species generated in the skin by UV irradiation promote photoaging and photocarcinogenesis. Superoxide dismutase is a primary antioxidant enzyme that crucially contributes to the homeostasis of oxygen radicals within the mitochondria, and thus critically participates in the control of senescence and tumor generation.”

When topically applied to the skin, it has a special ability to reverse the vasoconstriction to the skin, and this reversal of vascular spasm occurs “… when reactive oxygen species are scavenged by superoxide dismutase.”

Superoxide dismutase works strongly against photoaging, a factor of increasing importance because:

“The recent increase of ultraviolet rays on the Earth due to the increasing size of the ozone hole is harmful to life and to accelerate premature photo-aging of the skin. The detrimental effects of UV radiation on the skin are associated with the generation of reactive oxygen species such as superoxide anion radical, hydrogen peroxide, hydroxyl radical, and singlet oxygen. In this study, we report first in vivo detection and imaging of the generated reactive oxygen species in the skin of live mice following UVA irradiation. In addition, we found that the superoxide radical is formed spontaneously and singlet oxygen is generated in the UVA-irradiated skin.”

Note:     The superoxide oxygen radical is the specific target for the superoxide dismutase antioxidant enzyme. That’s one of the main reasons we included it in our Naturalift MD: Advanced Face Lift Therapy formula.

To evaluate sugar-caused advanced glycenation end-products (AGE) and its ability to cause more harm from sunlight exposure, researchers conducted a detailed biochemical study on human skin fibroblast cells. They reported:

“To clarify a possible role of advanced glycation end-products (AGE) on photoaging of human skin, the interaction between AGE and ultraviolet-A light was examined from both a biological and chemical perspective. Human dermal fibroblasts that were exposed to UVA and AGE exhibited significant decrease of cell viability. Unstable free radicals including hydrogen peroxide and hydroxyl radicals, were also generated. The reaction was inhibited by addition of superoxide dismutase in the system.”

Ursolic Acid.  Topically applied, ursolic acid reduces wrinkles in the skin by increasing the natural collagen content in skin. This benefit is achieved by increasing the production of fibroblast cells in the dermis as well as increasing the ceramide content of the epidermis. Ursolic acid “… prevents premature aging of the skin.”

“Ursolic acid significantly suppressed UVA-induced reactive oxygen species production and lipid peroxidation. Pretreatment with ursolic acid significantly reduced the UVA-induced activation and expression of MMP-2. In addition, UVA-induced enhanced expression of p53, a hallmark of UV-induced DNA damage and cell death, was also significantly inhibited by pretreatment with ursolic acid. Taken together, these results suggest that ursolic acid may be an effective inhibitor of UVA-modulated signal transduction pathways in human skin cells. These results further suggest that this agent may be useful in the prevention of UVA-induced photo-aging.

Vitamin A (Retinyl Palmitate & Retinol). A one-year study on facial skin aging and topically applied retinaldehyde reported:  “…[c]ompared to the control group, retinaldehyde treatment induced a significant increase in epidermal thickness of the temple, as well as cutaneous (skin) elasticity. Retinaldehyde has counteracting effects on skin aging.”  Retinyl palmitate and Retinol are two of the safe precursors of vitamin A.

The biological reasons for many of the anti-photoaging effects of retinol include:

“…vitamin A, retinol, and retinaldehyde have free radical scavenging potential. Due to their physical properties, they absorb UV light in the region of the solar spectrum that is responsible for the most deleterious biological effects of the sun.”

and

“…Interfering with this UV-induced vitamin A deficiency (using topical vitamin A precursors) is a new concept for the prevention of skin cancer and aging.”

A measurement for the amount of DNA damage is the amount of thymine dimers present in the skin. Skin loaded with vitamin A as retinyl-esters, after applying sufficient amounts of retinol, retinyl palmitate, and retinaldehyde topically, and exposed to sunlight sufficient to cause four times the minimal erythema dose, reduced production of thymine dimers by 43%. In human subjects, this form of topical therapy:

“…was as efficient as a sun protection factor 20 sunscreen in preventing sunburn erythema as well as the formation of thymine dimers. These results demonstrate that epidermal retinyl esters have a biologically relevant filter activity and suggest, besides their pleomorphic biologic actions, a new role for vitamin A that concentrates in the epidermis.”